Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

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Lingxin Chen ,* a

Shoufang Xu ab  and

Jinhua Li a

Author affiliations

* Corresponding authors

a Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China E-mail: lxchen@yic.ac.cn Fax: +86-535-2109130 Tel: +86-535-2109130

b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction , chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites , template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT , particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT , and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).

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Lingxin Chen ,* a. Shoufang Xu ab  and. Jinhua Li a. Author affiliations. * Corresponding authors. a Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China E-mail: lxchen@yic.ac.cn Fax: +86-535-2109130 Tel: +86-535-2109130. b Graduate University of Chinese Academy of Sciences, Beijing 100049, China. Abstract. Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction , chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites , template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT , particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT , and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references). Please wait while we load your content... Something went wrong. Try again?