Our AI writing assistant, WriteUp, can assist you in easily writing any text. Click here to experience its capabilities.

MAD2L2, a key regulator in ovarian cancer and promoting tumor progression


This article examines MAD2L2, a chromatin-binding protein and a component of DNA polymerase ζ, as a key regulator in ovarian cancer and its role in promoting tumor progression. The authors use bioinformatics tools, Cox Regression analysis, and in vitro cell experiments to investigate its biological functions. Results show that MAD2L2 typically undergoes genomic alterations, such as amplifications and deep deletions, and is overexpressed in OVCA patients, correlating with reduced survival rates. Additionally, it is found to be involved in tumor metabolism, the cell death process, and promoting cell proliferation and migration in OVCA cells. These findings offer new insights for treating OVCA.


What is MAD2L2?
MAD2L2 is a chromatin-binding protein and a component of DNA polymerase ζ.

What role has MAD2L2 been identified as in tumor growth?
MAD2L2 has been previously identified as an inhibitor of tumor growth in colorectal cancer.

What is the prognostic significance of MAD2L2 in ovarian cancer?
The prognostic significance of MAD2L2 in ovarian cancer is that its overexpression correlates with reduced survival rates, particularly in those with Grade IV tumors.

What biological functions does MAD2L2 have in ovarian cancer?
MAD2L2 is predominantly localized in the organellar ribosome, engaging mainly in NADH dehydrogenase activity. It is also involved in tumor metabolism and the cell death process.

How does upregulation of MAD2L2 affect cell behavior in ovarian cancer?
Upregulation of MAD2L2 enhances cell proliferation and migration in OVCA cells and inhibits the ferroptosis process, coinciding with increased mTOR signaling activity in these cells.

AI Comments

👍 This article provides valuable insights into the role of MAD2L2 in ovarian cancer, such as its expression, impact, and prognostic significance. The authors used comprehensive bioinformatics tools and in vitro experiments to uncover new information about this important protein.

👎 The article fails to provide any clear recommendations for using this information to develop new treatments for ovarian cancer, leaving readers with no practical applications for the research discussed.

AI Discussion

Me: It discusses MAD2L2, which is a key regulator in ovarian cancer and how it can promote tumor progression. The authors of the article studied its biological functions in OVCA patients and found that it's overexpressed in OVCA patients and has a correlation with reduced survival rates. They also found that it can promote cell proliferation and migration in OVCA cells, and that it can inhibit the ferroptosis process in these cells.

Friend: That's really interesting. What are the implications of this study?

Me: Well, the implications of this study are that MAD2L2 can be used as a target for treating ovarian cancer. It can also be used to prognosticate the survivability of OVCA patients, which could be a huge help for physicians in developing personalized treatment plans. Additionally, it could lead to new insights on how to regulate the ferroptosis process in OVCA, which could help to prevent tumor progression and improve patient outcomes.

Action items

Technical terms

Mitotic Arrest Deficient 2 Like 2, a chromatin-binding protein and a component of DNA polymerase ζ
Ovarian cancer
PubMed Identifier, a unique number assigned to each PubMed citation
PubMed Central Identifier, a unique number assigned to each article in PubMed Central
Digital Object Identifier, a unique alphanumeric string assigned by a registration agency to identify content and provide a persistent link to its location on the internet
Medical Subject Headings, a controlled vocabulary used for indexing articles in PubMed
Kyoto Encyclopedia of Genes and Genomes, a database resource for understanding high-level functions and utilities of the biological system

Similar articles

0.92383736 The promoting effect and mechanism of MAD2L2 on stemness maintenance and malignant progression in glioma

0.9144683 MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex

0.90742105 Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

0.8932164 FOXM1 is critical for the fitness recovery of chromosomally unstable cells

0.89132637 Biallelic MAD2L1BP (p31comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors

🗳️ Do you like the summary? Please join our survey and vote on new features!