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HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

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Summary

In this study, researchers investigated HPV-induced host epigenome-wide changes in cervical samples from women with or without an oncogenic HPV infection. The researchers developed the WID-HPV, a signature reflective of changes in the healthy host epigenome related to high-risk HPV strains. They found that HPV-infected women with minor cytological alterations (cervical intraepithelial neoplasia grade 1/2, CIN1/2) showed an increased WID-HPV index, indicating a successful viral clearance response. However, this response was absent in progression to cancer. The WID-HPV was positively associated with apoptosis and negatively associated with epigenetic replicative age. These findings suggest the WID-HPV captures a clearance response associated with apoptosis of HPV-infected cells, which may be lost in progression to cancer.

Q&As

What is the impact of a pathogen on host disease?
The impact of a pathogen on host disease can only be studied in samples covering the entire spectrum of pathogenesis.

What is the most common cause for cervical cancer?
Persistent oncogenic human papilloma virus (HPV) infection is the most common cause for cervical cancer.

What is the WID-HPV index?
The WID-HPV is a signature reflective of changes in the healthy host epigenome related to high-risk HPV strains.

How does the WID-HPV index reflect a successful viral clearance response?
The WID-HPV captures a clearance response associated with apoptosis of HPV-infected cells.

What are the associated factors with progression to cervical cancer?
The associated factors with progression to cervical cancer are dampened or lost clearance response associated with apoptosis of HPV-infected cells and increased underlying replicative age of infected cells.

AI Comments

👍 This article provides an in-depth insight into the epigenetic changes that occur in the host as a result of HPV-induced cancers. It also highlights the importance of early detection and screening in order to prevent the progression to high-grade cervical intraepithelial neoplasia.

👎 This article lacks any concrete conclusions regarding the impact of HPV-induced cancers on the host epigenome and fails to provide any potential solutions for the prevention of such cancers.

AI Discussion

Me: It's about how HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia. The article suggests that this may be due to a successful viral clearance response that is dampened or lost with increased underlying replicative age of infected cells, resulting in progression to cancer.

Friend: That's really interesting. What are the implications of this article?

Me: The implications of this article are that it provides us with a better understanding of how HPV infections lead to cervical cancer, which could help us to develop better treatments and prevention strategies. Additionally, the article's findings highlight the importance of early detection and screening for HPV infections, in order to prevent the progression to cervical cancer.

Action items

Research current HPV prevention and screening methods.
Investigate the potential of epigenetic reprogramming as a treatment for HPV-induced diseases.
Explore the role of apoptosis in HPV-induced host epigenetic reprogramming.

Technical terms

HPV-induced host epigenetic reprogramming: The changes in the host's epigenome (the chemical modifications to DNA that control gene expression) caused by the human papillomavirus (HPV).
High-grade cervical intraepithelial neoplasia (CIN): A precancerous condition of the cervix caused by HPV infection.
DNA methylation: A process by which methyl groups are added to the DNA molecule. This process is important for the regulation of gene expression.
Apoptosis: A type of programmed cell death that occurs in multicellular organisms.
Epigenetic replicative age: A measure of the number of times a cell has divided, which can be used to estimate the age of a cell.
AUC: The area under the curve, which is a measure of the accuracy of a diagnostic test.